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Prometrium & P4 Blood Level


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#1 sophie3

sophie3
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Posted 04 April 2011 - 04:54 PM

Hi,

Does vaginal prometrium affect blood levels of progesterone? Could 600mg (200 3x p/day) vaginally produce a 12 DPO blood p4 level of 60? My beta is only 3.4, so I know this is probably not viable, but wondering if the prometrium is responsible for the very high p4 level.

Thanks!
sophie

#2 David Corley MD

David Corley MD
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Posted 07 April 2011 - 04:11 AM

Sophie3,
To answer you question more data is required. How did you stimulate? How many follicles? What type of treatment?
Other factors besides the prometrium could have elevated your P4. When I use prometrium, I use it orally and not virginally. You will see elevated P4 levels with the oral route. Most of the approved vaginal progesterones do not substantially increased the blood level. Patients using the injectable progesterone may have levels 200-400.
Best wishes
David Corley, M.D.
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